Capabilities
Library screening: Screen your library to identify high quality starting points for your program.
- Deliverables: % of inhibition or activation.
- Application: Hit finding.
Dose-response profiling: Efficiently explore and optimize Structure Activity Relationships (SAR).
- Deliverables: Kd or IC50.
- Application: hit-to-lead and lead optimization.
Kinetic profiling of reversible inhibitors: Boost decision-making with parallel Structure Activity (SAR) and Kinetic Relationship (SKR) iterations, understand PK/PD disconnects and build better models to define therapeutic windows.
- Deliverables: Kd, kon, koff and residence time.
- Application: hit-to-lead, lead optimization and candidate selection.
Kinetic profiling of irreversible inhibitors: Identify irreversible compounds, rank inhibitor binding and covalent bond formation (SAR), define selectivity and interpret in vivo target occupancy.
- Deliverables: KI, kinact, Kinact/KI.
- Application: hit-to-lead, lead optimization and candidate selection.
Mechanistic assays: Get a better understanding of the drug-target interaction on a molecular level.
- Deliverables: Determination of the mechanism of inhibition (competitive, non-competitive or uncompetitive) and inhibition constants (Ki, aKi).
- Application: lead optimization and candidate selection.
Features and Benefits
- Flexible access to a wide range of assay readouts and technology formats:
- Fluorescent Intensity.
- Fluorescent Resonance Energy Transfer.
- Time-Resolved Fluorescence (TR-FRET, HTRF®, Transcreener®).
- Fluorescence Polarization (IMAP®).
- AlphaLisa® & AlphaScreen® based chemiluminescence.
- Luminescence (ADP-GLO®).
- Reliable and quick turnaround times
- Accurate, precise & reproducible data
- Integration with custom assay development to provide novel solutions
- Free internal resources to focus on other activities
- A continuous interaction with our clients on the progress of a screening project

How can we help?
Our experienced project manager will work with you to identify the best way forward for your project.