Supercharge Your Path to Breakthroughs in Transcription Factor Discovery
With over 1,600 members in the human genome, transcription factors are the master regulators of gene expression, governing the activity of nearby genes and orchestrating cellular responses to internal and external stimuli. Nearly 19% are linked to disease, underscoring their central role in biology. Despite their importance, they remain one of the most underexploited target classes in drug discovery, representing a major opportunity for innovation.
Technology
List of targets ready to use
Our expertise extends beyond kinases to GPCR and other target types.
Search our database to discover whether your target is:- May be possible: We have a strong track record of achievement where others fail! Contact us to find out more.
- Clear line of sight: Establishment requires finalization / validation, which typically takes 2-4 weeks to complete.
- Good to go: Data within 2 weeks of compound receipt.
* Full length and partial length forms are available.
| Target name | Alternative names | KINETICfinder | COVALfinder |
|---|---|---|---|
| AAK1 | KIAA1048, DKFZp686K16132 | Clear line of sight | |
| ABL1 | ABL, c-ABL1, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, p150, v-abl | Good to go | |
| ABL1 E255K | ABL, c-ABL1, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, p150, v-abl | Clear line of sight | |
| ABL1 G250E | ABL, c-ABL1, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, p150, v-abl | Clear line of sight | |
| ABL1 H396P | ABL, c-ABL1, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, p150, v-abl | Clear line of sight | |
| ABL1 M351T | ABL, c-ABL1, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, p150, v-abl | Clear line of sight | |
| ABL1 Q252H | ABL, c-ABL1, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, p150, v-abl | Clear line of sight | |
| ABL1 Y253F | ABL, c-ABL1, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, p150, v-abl | Clear line of sight | |
| ABL2 (ARG) | ARG, ABL isoform b, ABLL | Good to go | |
| ACK (TNK2) | TNK2, ACK-1, ACK1, p21cdc42Hs | Good to go | |
| ACVR2A | ACTRII, ACTR2, ACVR2 | Clear line of sight | |
| ACVR2B | ACTRIIB, ActR-IIB, HTX4 | Clear line of sight | |
| AKT1 | AKT1, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA, | Good to go | Good to go |
| ALK | ALK, CD246, NBLST3 | Good to go | May be possible |
| ALK C1156Y | ALK, CD246, NBLST3 | Clear line of sight | |
| ALK F1174L | ALK, CD246, NBLST3 | Clear line of sight | |
| ALK L1196M | ALK, CD246, NBLST3 | Clear line of sight | |
| ALK R1275Q | ALK, CD246, NBLST3 | Clear line of sight | |
| ALK T1151_L1152insT | ALK, CD246, NBLST3 | Clear line of sight | |
| ALK1 (ACVRL1) | ALK1, ALK-1, ACVRLK1, HHT, HHT2, ORW2, SKR3, TSR-I | Good to go | May be possible |
Helpful resources
How can we help?
Our experienced project manager will work with you to identify the best way forward for your project.